منابع مشابه
Gastric carcinogenesis.
Currently, gastric adenocarcinoma is still a serious healthcare concern, and the second most frequent malignancy worldwide (1). Although overall incidence has seemingly decreased, both its frequency and mortality rate show relevant geographic variability. In Eastern countries, Eastern Europe, and South America the incidence of this disease reaches epidemic proportions, and is the first cause of...
متن کاملMolecular events in gastric carcinogenesis
Gastric cancer represents an important problem for the public health, being one of the main causes of mortality. At present, it represents the second cause of mortality due to cancer, after the bronchopulmonary cancer in men and the fourth cause of mortality in women. Important progresses have been made in the last couple of years in determining the neoplastic etiopathogenesis, but it cannot be...
متن کاملCell recruitment in gastric carcinogenesis
th most common malignant disease and the 3 rd leading cause of cancer death worldwide. Like most cancers, incidence increases with age. Unlike most other cancers a dominant environmental cause has been established, as chronic infection by Helicobacter pylori contributes about 90% of the attributable risk in " non-cardia " gastric cancer, the most common type globally [1]. The development of gas...
متن کاملMouse Models of Gastric Carcinogenesis
Gastric cancer is one of the most common cancers in the world. Animal models have been used to elucidate the details of the molecular mechanisms of various cancers. However, most inbred strains of mice have resistance to gastric carcinogenesis. Helicobacter infection and carcinogen treatment have been used to establish mouse models that exhibit phenotypes similar to those of human gastric cance...
متن کاملImmunohistochemical Analysis of LGR5 and TROY Expression in Gastric Carcinogenesis Demonstrates an Inverse Trend
Background: Two of the Wnt signaling pathway target genes, tumor necrosis factor receptor family member (TROY) and leucine-rich G-protein coupled receptor (LGR5), are involved in the generation and maintenance of gastrointestinal epithelium. A negative modulatory role has recently been assigned to TROY, in this pathway. Here, we have examined their simultaneous expression in gastric carcinogene...
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ژورنال
عنوان ژورنال: Revista Española de Enfermedades Digestivas
سال: 2004
ISSN: 1130-0108
DOI: 10.4321/s1130-01082004000400006